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DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

TitleDisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation
Publication TypeJournal Article
Year of Publication2021
AuthorsQuaglia, Federica, Bálint Mészáros, Edoardo Salladini, András Hatos, Rita Pancsa, Lucía B. Chemes, Mátyás Pajkos, Tamas Lazar, Samuel Peña-Díaz, Jaime Santos, Veronika Ács, Nazanin Farahi, Erzsébet Fichó, Maria Cristina Aspromonte, Claudio Bassot, Anastasia Chasapi, Norman E Davey, Radoslav Davidović, Laszlo Dobson, Arne Elofsson, Gábor Erdős, Pascale Gaudet, Michelle Giglio, Juliana Glavina, Javier Iserte, Valentín Iglesias, Zsófia Kálmán, Matteo Lambrughi, Emanuela Leonardi, Sonia Longhi, Sandra Macedo-Ribeiro, Emiliano Maiani, Julia Marchetti, Cristina Marino-Buslje, Attila Mészáros, Alexander Miguel Monzon, Giovanni Minervini, Suvarna Nadendla, Juliet F. Nilsson, Marian Novotný, Christos A Ouzounis, Nicolás Palopoli, Elena Papaleo, Pedro José Barbosa Pereira, Gabriele Pozzati, Vasilis J Promponas, Jordi Pujols, Alma Carolina Sanchez Rocha, Martin Salas, Luciana Rodriguez Sawicki, Eva Schad, Aditi Shenoy, Tamás Szaniszló, Konstantinos D Tsirigos, Nevena Veljkovic, Gustavo Parisi, Salvador Ventura, Zsuzsanna Dosztányi, Peter Tompa, Silvio C. E. Tosatto, and Damiano Piovesan
JournalNucleic Acids Research
Volume50
PaginationD480-D487
Date Published11
ISSN0305-1048
Abstract

{The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30\%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.}

URLhttps://doi.org/10.1093/nar/gkab1082
DOI10.1093/nar/gkab1082


by Dr. Radut.