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Vasilis Promponas


Short Bio  

I hold a PhD from the University of Athens, Greece and currently head the Bioinformatics Research Laboratory in the Department of Biological Sciences at the University of Cyprus. 

Our research in computational biology and bioinformatics is mainly oriented towards the interpretation of large scale genomic and biological data in order to reveal the principles governing the molecular basis of life.

Along these lines, we develop/utilize computational methods (empirical, statistical and machine/deep learning) that exploit any available type of biological information (e.g. macromolecular sequences and structures, gene expression data, biomedical literature) towards understanding biological systems, ranging from macromolecules and macromolecular complexes, to phenotypes.

I have a long-standing interest in the study of classes of non-globular proteins (e.g. transmembrane proteins, protein sequences with local compositional biases or repeats) and during the last decade we have focused our research on protein components of eukaryotic endomembrane systems, in particular nuclear pore complex subunits and components of the autophagy machinery.

More specifically, we devise algorithms, methods/tools, databases and computer systems for:

  • Protein sequence analysis and structural bioinformatics, e.g. repeats, low complexity/compositional bias, intrinsic struc- tural disorder, (trans)membrane proteins.
  • Computational comparative genomics, e.g. evolution of low complexity/compositionally biased sequences, computational approaches for synthetic biology (recently with wet-lab expansion).
  • Biomedical text mining and its applications in biocuration (with a focus in autophagy).

I am currently an editorial board member for PLoS One (Academic Editor, since 2011), Computational and Structural Biotechnology Journal (since 2012) and Journal of Biological Research-Thessaloniki (since 2014) and I have reviewed for major journals of the field (e.g. Bioinformatics, Briefings in Bioinformatics, Nucleic Acids Research, Nucleic Acids Research Genomics and Bioinformatics, PLoS Computational Biology, Biosystems, Proteins: Structure, Function and Bioinformatics, BMC Genomics, Microbial Genomics)

I am a member of the International Society for Computational Biology (ISCB), a founding officer and a former Board member of the Hellenic Society for Computational Biology and Bioinformatics (HSCBB), founding member of Hellenic Bioinformatics, and of the Society of Biological Sciences in Cyprus.


[List of publications] [Google Scholar Profile]



by Dr. Radut.