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Annotation inconsistencies beyond sequence similarity-based function prediction - phylogeny and genome structure.

TitleAnnotation inconsistencies beyond sequence similarity-based function prediction - phylogeny and genome structure.
Publication TypeJournal Article
Year of Publication2015
AuthorsPromponas, V. J., Ioannis Iliopoulos, and Christos A. Ouzounis
JournalStandards in genomic sciences
Volume10
Pagination108
Date Published2015
ISSN1944-3277
Abstract

The function annotation process in computational biology has increasingly shifted from the traditional characterization of individual biochemical roles of protein molecules to the system-wide detection of entire metabolic pathways and genomic structures. The so-called genome-aware methods broaden misannotation inconsistencies in genome sequences beyond protein function assignments, encompassing phylogenetic anomalies and artifactual genomic regions. We outline three categories of error propagation in databases by providing striking examples - at various levels of appreciation by the community from traditional to emerging, thus raising awareness for future solutions.

DOI10.1186/s40793-015-0101-2
Alternate JournalStand Genomic Sci


by Dr. Radut.